Fish Oil Research Today is a free monthly online journal that collates and summarizes the latest research about Fish Oil, including details on omega-3, dosage, health benefits, diet.

Effects of omega-3 fatty acid supplementation on vascular access thrombosis in polytetrafluorethylene grafts.

Bowden RG, Wilson RL, Gentile M, Ounpraseuth S, Moore P, Leutholtz BC

Department of Health, Human Performance, and Recreation, Center for Exercise, Nutrition, and Preventive Health Research, Baylor University, Waco, TX 76798-7313, USA. Rodney_Bowden@baylor.edu

OBJECTIVE: The purpose of this study was to investigate the effects of orally administered over-the-counter omega-3 (n-3) fatty acid supplements on primary patency of polytetrafluoroethylene (PTFE) grafts. DESIGN: This study was conducted with a triple-blind, permuted-block, randomized, placebo-controlled experimental design. SETTING: Dialysis clinics with patients who, in accordance with physician diagnosis, needed a new PTFE graft. PATIENTS AND OTHER PARTICIPANTS: Patients on long-term hemodialysis with newly placed PTFE grafts who were unable to receive a native arteriovenous fistula. INTERVENTION: Patients were followed prospectively for 8 months after they had been placed into an n-3 fatty acid or control group and were monitored for primary patency. MAIN OUTCOME VARIABLE: Primary patency of the PTFE graft. RESULTS: The n-3 fatty acid group had a mean PTFE graft primary patency rate of 254.2 days (SEM = 51.8), and the control group had a mean PTFE graft primary patency rate of 254.1 days (SEM = 34.6), revealing no significant difference in survival time between groups. CONCLUSIONS: No significant differences in primary patency rates were noted in the experimental and control groups.

Published 26 February 2007 in J Ren Nutr, 17(2): 126-31.
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