Fish Oil Research Today is a free monthly online journal that collates and summarizes the latest research about Fish Oil, including details on omega-3, dosage, health benefits, diet. | ||||||||
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Inflammatory markers are not altered by an eight week dietary alpha-linolenic acid intervention in healthy abdominally obese adult males and females.Nelson TL, Stevens JR, Hickey MS Human Performance Clinical/Research Laboratory, Department of Health and Exercise Science, Colorado State University, 223 Moby, Fort Collins, CO 80525, USA. Atherogenesis is thought to be mediated by local and/or systemic production of pro-inflammatory cytokines and omega-3 fatty acids have been implicated in reducing these inflammatory markers. The objective of this study was to determine the effect of an isocaloric diet supplemented with a plant-based dietary omega-3 fatty acid [alpha-linolenic acid (ALA)] on interleukin-6, C-reactive protein, serum amyloid A, and tumor necrosis factor-alpha. Subjects included healthy adult males and females ( approximately 79% female, average age 38years) with increased waist circumference (mean WC=99cm) and body mass index (mean BMI=29.8kg/m(2)) who were free of chronic disease, not taking medications, and sedentary. Control subjects (n=24) did not to alter their habitual diet and the ALA group (n=27) followed an enriched ALA diet by using flaxseed oil capsules (increasing ALA to 5% of total energy intake) and lowered their dietary fat consumption by a commensurate amount. Fasting blood samples were obtained before and after the 8-week intervention. We found no significant changes in the inflammatory factors after this 8-week dietary intervention. This study suggests there are no beneficial effects of an 8-week ALA intervention on these inflammatory factors among young, healthy, overweight/obese subjects whose inflammatory factors are not significantly elevated. Published 25 July 2007 in Cytokine, 38(2): 101-6.
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