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Plasma free fatty acid level patterns according to cardiovascular risk status in postmenopausal women.

Rhee Y, Paik MJ, Kim KR, Ko YG, Kang ES, Cha BS, Lee HC, Lim SK

Department of Internal Medicine & Endocrine Research Institute, College of Medicine, Yonsei University, Seoul, Republic of Korea.

BACKGROUND: The present study examines changes in the pattern of plasma free polyunsaturated fatty acids (PUFA) according to menopausal status and the existence of diabetes mellitus (DM) or coronary heart disease (CHD) in Korean women. METHODS: The participants were as follows; premenopausal women (PRE, n=20) and postmenopausal women without any known chronic disease (POST, n=35), with DM (DM, n=35), or with angiographically proven CHD (CHD, n=30). Plasma free fatty acids were measured in all participants. RESULTS: Healthy premenopausal women had a higher ratio of omega-3/omega-6 PUFA than postmenopausal women (p=0.001). As expected, the PRE group had higher docsapentaenoic acid (DPA) and docosahexaenoic acid (DHA) levels (p<0.05) and lower arachidonic acid levels (p<0.05) than the POST group. In turn, the healthy POST group had higher levels of DPA and DHA compared to the DM or CHD groups (p<0.05). There were significant shifts of increased omega-6 and decreased omega-3 among the women, according to each disease. CONCLUSIONS: There was a significant relationship between omega-3 and omega-6 PUFA profiles and risk for CHD in women. This metabolic profile of PUFA might be an important surrogate marker in postmenopausal women.

Published 6 May 2008 in Clin Chim Acta, 392(1): 11-6.
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